The dynamics of diplomatic relations between the United States (US) and China have been the main focus in the global political arena throughout the last decade. These two countries, which are the two largest economic powers in the world, have a complex relationship, characterized by varying degrees of cooperation and tension. One important aspect of this relationship is trade. The US and China are major trading partners, but the trade imbalance is attracting the attention of authorities in Washington. The US trade deficit with China, which stands at more than $300 billion annually, has become a focal point of tension. The imposition of tariffs by the US on Chinese goods under the Trump administration triggered a trade war that had a significant impact on both economies. Apart from trade, technological issues also influence this dynamic. Competition in the technology sector, including the development of artificial intelligence and 5G, is creating further tensions. The US considers that China steals technology and engages in unfair trade practices, raising concerns about national security. Strict control of companies such as Huawei and TikTok are concrete steps in responding to this issue. One of the increasingly heated conflicts is related to Taiwan. The US has official relations with Taiwan and promotes a “One China” policy that recognizes Beijing’s government but does not officially recognize China’s sovereignty over Taiwan. Tensions rise every time the US sends a delegation to Taiwan or sells modern weapons to the island. China responded with military threats, increasing tensions in the Taiwan Strait. Apart from that, human rights issues in Xinjiang and Tibet as well as the handling of protests in Hong Kong are additional highlights. The US has consistently condemned human rights violations occurring in the region, creating further divisions. China retaliated by accusing the US of interfering in its internal affairs, pushing the narrative that the US is a human rights abuser in its own historical context. Diplomatic dynamics are also influenced by each country’s global presence. The US is implementing a strategy to build alliances with countries in the Indo-Pacific region, while China is increasingly active in strengthening global infrastructure networks through the Belt and Road Initiative. China’s efforts to expand its influence are often seen by the US as a threat to regional and global stability. Global health crises, such as the COVID-19 pandemic, have also affected diplomatic relations. The US and China blame each other regarding the origin of the virus and its handling. This incident shows how fragile international relations are affected by broader health and security issues. In facing these challenges, diplomacy remains an important tool for both countries. High-level meetings, negotiations and dialogue continue to be sought to reduce tensions. Despite many differences, awareness of the need for cooperation in the fields of climate change and global health emerged as an opportunity to create synergy between the two countries. Future relations between the US and China will be greatly influenced by the two countries’ ability to find common ground on the issues that divide them. Key elements to this relationship include policy adaptation, addressing military intimidation, and a commitment to constructive dialogue. This relationship not only affects the two countries, but also overall global stability and security.